目的 研究抗癌平分散片的制备工艺与处方。方法 采用正交实验设计优化中药材水提工艺、提取物的喷雾干燥工艺和分散片处方。结果 确立最优水提工艺参数为8倍加水量,提取2次,每次煎煮时间60 min;提取物喷雾干燥最优工艺参数为药液密度1.20 g·mL-1,进风温度为180 ℃,出风温度为80 ℃;最优处方比例为微晶纤维素加入量37%,交联羧甲基纤维素钠与交联聚乙烯吡咯烷酮加入量之比为5∶1,硬脂酸镁0.15%。结论 采用正交实验设计优化的工艺处方可以用于制备抗癌平分散片。
Abstract
OBJECTIVE To study preparation process and formula of Kang′aiping dispersible tablets.METHODS Orthogonal designs were used to optimize water extraction process of traditional Chinese herbs from Kang′aiping pills, spray drying process of extracts and formulas of Kang′aiping dispersible tablets.RESULTS The optimal water-extraction process is established by adding eight times water of raw materials, boiling for 60 min and extracting for two times. The optimal spray drying process parameters are that the density of the liquid extracts is 1.20 g·mL-1, inlet air temperature is 180 ℃ and outlet air temperature is 80 ℃. And the optimal formula consists of 37% microcrystalline cellulose, 5∶1 of the ratio of croscarmellose sodium and PVPP, and 0.15% magnesium stearate. CONCLUSION Formula and process optimized by using orthogonal experimental design is suitable for preparation of Kang′aiping dispersible tablets.
关键词
抗癌平分散片 /
正交实验设计 /
优化 /
水提法 /
喷雾干燥
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Key words
Kang′aiping dispersible tablets /
orthogonal experimental design /
optimization /
water extraction /
spray drying
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中图分类号：
R944
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